Fig. 8

The Cytoscape based interaction network analyzing the ranking of the interacting partners based on the degree of interaction, betweenness centrality, and bottleneck approach to identify the hub and bottleneck genes. I PPI network for upregulated genes imported to Cytohubba plugin showing the topmost hits based on degree of interaction II. bottleneck approach III. betweenness centrality IV. PPI network for down-regulated genes imported to Cytohubba plugin showing the 10 topmost hits based on degree of interaction V. hits obtained through bottleneck approach. VI. hits obtained from betweenness centrality